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02 May Dapoxetine: Key Insights

Posted at 17:56h in Development by
Characteristic Details
Generic Name Dapoxetine
Brand Names Priligy, Westoxetin
Dosage Forms 30mg, 60mg
Indications Premature Ejaculation
Availability Prescription Only
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Pharmacokinetics of Dapoxetine

Dapoxetine, commonly branded as Priligy, exhibits rapid absorption with peak plasma concentrations achieved within 1 to 2 hours post-administration. Its bioavailability stands at approximately 42%. The pharmacokinetics of Dapoxetine 60mg are linear over its dosing range, with its half-life being around 19 hours. The substance is extensively metabolized in the liver, primarily by CYP2D6 and CYP3A4 enzymes.

Distribution of dapoxetine is significant, with a volume of distribution of 162 liters. Its high protein-binding affinity is noted at 99%, which influences its interaction profile with other drugs. The drug and its metabolites are excreted predominantly through urine, necessitating renal function assessment prior to prescribing. The pharmacokinetic profile suggests adjustments in individuals with hepatic or renal impairment.

Mechanism of Action

Dapoxetine functions as a selective serotonin reuptake inhibitor (SSRI), yet it is distinct in its short-acting nature. It modulates serotonin levels in the synaptic cleft, enhancing its activity, which plays a pivotal role in delaying ejaculation. This mechanism underpins its primary use in treating premature ejaculation. The efficacy of Dapoxetine 30mg relies on its rapid action, aligning with its intended use on-demand.

The enhancement of serotonergic neurotransmission is key. This modulation leads to increased pudendal nerve reflex latency. As a result, control over ejaculatory response improves, granting patients increased satisfaction. Dapoxetine’s pharmacodynamic attributes make it uniquely suited for short-term application, unlike other SSRIs.

Warnings and Precautions

Healthcare professionals must note several warnings with dapoxetine use. Its administration is contraindicated in patients with significant cardiac history, including heart failure and arrhythmias. Caution is advised for those with underlying psychiatric disorders due to potential exacerbation of symptoms.

Patients should avoid alcohol, which may enhance orthostatic hypotension and increase sedation risks. Gradual position changes are recommended to prevent dizziness and syncope. Comprehensive patient history is crucial to mitigate risks associated with concurrent serotonergic drugs.

Dapoxetine Disposal

Proper disposal of dapoxetine is paramount. Unused medication should not be flushed down the toilet or thrown into household waste. Instead, utilize drug take-back programs where available. This ensures environmental safety and prevents accidental ingestion.

In the absence of such programs, mix the tablets with an undesirable substance like used coffee grounds or cat litter. Seal this mixture in a container before disposing it in the trash. Proper disposal curbs misuse and safeguards public health.

Side Effects of Dapoxetine

The side effect profile of dapoxetine includes nausea, headache, dizziness, and diarrhea. These are generally mild and transient. Severe reactions like syncope, mood swings, and serotonin syndrome are rare but warrant immediate medical attention.

Monitoring for adverse reactions, especially during initial use, is advisable. Dose adjustment or discontinuation may be necessary if side effects persist. Patient education on recognizing symptoms of serious side effects is essential.

Buying Dapoxetine Online

Dapoxetine can be procured online from verified pharmacies. Ensure the source is legitimate to avoid counterfeit medications. A prescription is mandatory for purchase due to its prescription-only status.

Online platforms may offer convenience and competitive pricing. However, caution must be exercised to ensure compliance with local regulations. Prioritize safety and authenticity over cost considerations.

Online pharmacy features to consider:

  • Verified pharmacy accreditation
  • Prescription requirement
  • Secure payment options

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